Bioengineered Mosquitoes to Fight Dengue

Researchers from the University of California, San Diego, Tata Institute of Genetics & Society, and Vanderbilt University Medical Center have genetically engineered a strain of mosquitoes that can effectively fight the dengue virus. The mechanism of action involves the expression of an antibody. When female Aedes aegypti mosquitoes take in blood, a specific type of antibody gets synthesized. This antibody is able to block the replication of the dengue virus. The expressed antibody efficiently combats four different strains of the deadly dengue virus. According to the World Health Organization, the dengue virus threatens millions of people across the globe. This groundbreaking research has been published in the journal PLOS Pathogens. Future work includes genetically engineering mosquitoes to fight the Zika, Yellow fever, and Chikungunya viruses.


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