HIV Vaccine Successfully Tested in Monkeys

Scripps researchers recently tested an HIV vaccine in monkeys. Rhesus macaque monkeys produced antibodies against a common strain of the HIV virus. The goal was to make these test animals produce neutralizing antibodies against the virus’ outer envelope protein trimer. A recently designed stable form of this trimer was used as an ingredient in the HIV vaccine. After vaccination, the test animals were exposed to an engineered version of the Tier 2 virus. Higher titers of the vaccine were found to be effective. The aim of this experiment was to identify the most vulnerable areas of the HIV virus and target antibody production against those. The research team now hopes to come up with a novel solution for producing broadly neutralizing HIV antibodies.

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